Introduction to toxicokinetics from the Royal National Academy of Pharmacy: An example of academic collaboration

This paper addresses the beginning of toxicokinetics in Spain by group Prof. Bartolomé Ribas 60s last century, as well interdisciplinary collaboration that occurs between academics Royal National Academy Pharmacy (RANF) and more specifically with Rafael Cadórniga, who was a pioneer Biopharmacy Pharmacokinetics studies Spain. scientific is magnificent example work strong interrelationship pharmacokinetics. The also develops concepts, methods advances toxicokinetics, focusing on analytical for determination very low concentrations toxic substances animal human organism, multicompartmental models, physiologically based toxicokinetic models (PBTK), / toxicodynamic (TX TD), population Bayesian future this discipline use methodologies artificial intelligence. Currently, plays fundamental role development new medicines, evaluation food safety environmental risks. Keywords: toxicokinetics; pharmacokinetics; ranf; academic